Posts Tagged ‘GAME CHANGER’

Inhibiting Protein PD-1: A Game Changer

June 10, 2015

Spring 2015/UCSF Magazine

Unleashing the Immune System: by Wallace Raven

“Oncologists are treating the immune system instead of tumors to fight cancer–with startling results.”

Adil Daud, MD, Director of Melanoma Clinical Research at UCSF’s Helen Diller Family Comprehensive Cancer Center, has had impressive results using a new drug, pembrolizumab.

“No other immunotherapy causes tumors to shrink in such a high percentage of patients, and these are lasting reponses,” explained Daud, theree years after the drug’s effect first became evident.  The drug works by inhibiting a protein called PD-1, an approach he calls a game-changer.”

Game Changer: Dwindling Resources

September 23, 2013

The Wall Street Journal: WSJ MONEY, Fall, 2013


THE GRANTHAM FILE:  A famed bad-news predictor is worried about dwindling resources–but sees opportunity, too. By Jan Salisbury

“Jeremy Grantham’s got a track record that’s impossible to ignore–he called the internet bubble, then the housing bubble.”  According to the article, in early 2009, the week stocks hit their “post Lehman low,” Mr. Grantham advised clients to get back into the market.  “Now, however, the outspoken Yorkshireman, who is chief investment strategist at GMO, is making headlines with a new prediction: Dire, Malthusian warnings about environmental catastrophe…

Question to Jeremy Grantham:  You’ve been ringing alarm bells about commodity prices.  Why all the worry?

Answer: They came down for a hundred years by an average of 70 percent, and then sorting around 2002, they shot up and basically everything tripled–and I mean everything.  I think tobacco was the only one that went down.  They’ve given back a hundred years of price decline and they gave it back between ’02 and ’08, in six years.  The game had changed.  I suspect the game changed because of the ridiculous growth rates in China–such a large country, with 1.3 billion people using 45 percent of the coal used in the world, 50 percent of all the cement and 40 percent of all the copper.  I mean these are numbers that you can’t keep on rolling along without expecting something to go tilt.

I italized sports terms that are used as idioms.  Track record is used in field sports, track and horse racing. It is also used to point out a long term accomplishment, for instance in financial predictions.  Game changer is used  not only in sports, but war, and other life activities.

Frank Deford, Commentator for NPR Speaks About Sports Idioms.

June 17, 2013

Mr. Deford’s September 26th NPR (National Public Radio) broadcast had this title:

RG3: A Game Changer for Thirds Everywhere

We’re all familiar with the many sports terms that have moved into general usage: “par for the course,” “slam-dunk,” “curveball,” “photo finish” and so on.  Curiously, though, every now and then something of the inverse occurs, and we get an expression which is commonly used that has been derived from sport, but never used in sport. For example, that awful, overdone cliche, “level playing field.” Never in my life have I ever heard anyone in sport — that is, somebody actually right there on the level playing field — say, “I’m glad we’re playing on a level playing field.”   

Mr. Deford  discussed a few other terms he had never heard anyone use in tennis:  The ball’s in your court, or It’s in your court.  And soccer moms: he had never heard anyone use that term about soccer moms in reference to soccer.  However, Mr. Deford, my niece’s school had soccer teams and a mother’s team called “Soccer Moms.”

 “Real games have turning points. But things that are not games have game changers:

Here, though, is a game changer, uniformwise, that especially interests me. The star rookie quarterback of the Washington Redskins is named Robert Lee Griffin III. And so far as I know, he is the first player ever — ever — in the entire history of sports uniforms, to have “the third” on his uniform. It says “GRIFFIN III.

Afghan Soldier’s Journey to Killer of Americans

January 9, 2013

The New York Times, Friday, January 4, 2013, by Matthew Rosenberg

A Shooting Followed By Taliban Embrace

Kabul, Afghanistan

A young Afghan soldier, named Mahmood, 22, his hatred so all consuming reached out to the Taliban to say he wanted to “shoot Americans” when he next visited the outpost where he was based in northeastern Afghanistan. 

This he did on the morning of May 11, “when he opened fire on American trainers who had gone to the outpost in the mountains of Kunar Province.  One American was killed and two others wounded.”  Mahmood escaped and joined the Taliban. 

“Such insider attacks, by Afghan security forces on their Western allies, became ‘the signature violence of 2012,’ in the words of one former American official.”  American officials are worried about the disruptive effects on the training mission that is the ore of the American withdrawal plan for 2014.”

‘It’s a game changer on all levels,’ said First Sgt. Joseph Hissong, an American who helped fight off an insider attack by Afghan soldiers that left two men in his unit dead.”

Mayonnaise Recipe Game Changer

May 29, 2012

New York Times, Wednesday, May 23, 2012


A GOOD APPETITE, Melissa Clark

“Don’t you know the mayonnaise trick? My friend Dori and I were standing in front of Empire Mayonnaise in Brooklyn..when she asked me that.  If there was a trick for making mayonnaise, I certainly did not know it.  And what a trick–a potential game-changer, the kind that turns homemade mayo from a special-occasion recipe into an everyday endeavor, ending our dependence on subpar, corn syrup filled commercial stuff.

Adding a teaspoon of water to the yolks before dripping in the oil helps create a stronger and more stable emulsion.”


July 6, 2011

The New York Times, Obituaries, Monday, July 4, 2011

Eddy Nicolson, 73, Colorful Collector, Dies,

by Paul Vitello

Mr. Nicolson was a business man, a leveraged-buyout pioneer who became an art and furniture collector.  “Mr. Nicolson’s style may have raised eyebrows, Mr. Hays (the deputy chairman of Christie’s America) said, but it also had a ‘democratizing effect on the insular world of art collecting.  He was a real game-changer.”

Mr. Hays changed the world of antique buying just as a great pitcher’s game, or outfielder’s catch, or umpire’s call can change a baseball game.

Game Changer

November 1, 2010

From a mailed Christian Church advertisement:  On the overleaf:  game changer

“-a person, an idea or an event that completely changes the way a situation develops”

(“In the left hand corner is a color picture of a baseball outfielder flying to catch a ball.)

(On the inside of the flyer is a picture of a football player being carried by his team after a successful game) and:


“But lasting change can be so difficult to achieve.  The good news is that God is in the life-changing business.  Join us at … Church as we explore together what it takes to make a change and become more like the people we wish we could be.  Be someone who takes a step toward real, posiive, life-change.. be a Game Changer.”

What you Know Can Change Your Life

Taking a Turn for the Best

When Losing is Winning

Keep the Change