Inhibiting Protein PD-1: A Game Changer

Spring 2015/UCSF Magazine

Unleashing the Immune System: by Wallace Raven

“Oncologists are treating the immune system instead of tumors to fight cancer–with startling results.”

Adil Daud, MD, Director of Melanoma Clinical Research at UCSF’s Helen Diller Family Comprehensive Cancer Center, has had impressive results using a new drug, pembrolizumab.

“No other immunotherapy causes tumors to shrink in such a high percentage of patients, and these are lasting reponses,” explained Daud, theree years after the drug’s effect first became evident.  The drug works by inhibiting a protein called PD-1, an approach he calls a game-changer.”


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